What is Revitalize?
New treatment that improves the quality of ova and the receptivity of the endometrium, thus increasing the chances of pregnancy.
An opportunity for women with a poor reproductive prognosis
The Revitalize treatment is a procedure developed by the team of physicians at Juana Crespo Clinic, which combines different techniques that were previously used separately and which, when combined and applied on a customized basis, improve the functioning of the ovaries and uterus.
Deployment of stem cells from bone marrow and the proprietary, innovative micro-puncture technique (micro-injections) of platelet-rich plasma improve oocyte quality, hence yielding better embryos, while also promoting optimal endometrial thickening, this led to significantly improved chances of pregnancy in women with very poor reproductive prognosis.
High-complexity patient profile
-
RFA < 5
Antral
follicle count -
≥ 35 years
-
AMH < 1.2 ng/ml
AMH:
Anti-Müllerian -
Little or no endometrial growth
-
< 4 Oocytes Retrieved in Previous Stimulations
RESULTS
This technique for regeneration of the endometrium is quite innovative, but it has achieved very good results in patients with lack of endometrial growth or sparse endometrial growth, even achieving an endometrial line optimal for embryo implantation. By mobilizing bone marrow stem cells and using our own innovative platelet-rich plasma microinjection technique, we achieve improved embryo quality and optimal endometrial thickening, resulting in a proven and effective improvement in the chances of a successful pregnancy in women with a very poor reproductive prognosis.
Pregnancy rate
77%
21.8%
Other centers
Evolutionary gestation
60%
16,7%
Other centers
When is
Revitalize indicated
Revitalize is indicated in patients with poor prognosis for assisted-reproduction treatments due to:
What does Revitalize
Treatment consist of
It consists of combining three techniques.
Phase of simulation of stem cells from bone marrow
In general, humans have a limited number of stem cells circulating in their blood. Thanks to a drug treatment tailored to the patient, we stimulate the production of these stem cells and mobilize them into the bloodstream, significantly increasing the initial number of stem cells.
Local administration of PRP (platelet-rich plasma) through micro-punctures
Once the previous phase has been completed, through a simple blood draw performed in our clinic, the sample is centrifuged and the patient's autologous PRGF sample is obtained.
Phase of stimulation of growth factors using a customized protocol
A global strategy
Types of
Revitalize
Treatment
Revitalize Ovaries promotes the transition of primordial or dormant follicles (the innate ovarian reserve of each woman) to antral follicles (those that are susceptible to stimulation), and hence it promotes production of mature ova in women with early menopause or premature ovarian insufficiency.
However, the success rate of pregnancy in treatments performed with Revitalize was 42% higher than that of other ovarian rejuvenation procedures, as they incorporate the surgical strategy of PRGF administration and endometrial stimulation and/or preparation in a fully personalized way.
Revitalize Ovaries
A woman’s ovarian reserve is made up of primordial follicles, so-called dormant follicles, which have been in the ovaries since birth. Each month the ovary activates about 1000 primordial follicles in a process that lasts for various months until they are transformed into a more complete structure, known as the antral follicles.
Revitalize Ovario, a highly
advanced ovarian rejuvenation
technique that works by:
-
Revitalize Ovaries promotes the transition of primordial or dormant follicles (the innate ovarian reserve of each woman) to antral follicles (those that are susceptible to stimulation)
-
Improving the functionality of the ovaries, so that they produce mature eggs.
-
Result: Quality embryos even in the most difficult cases.
The antral follicles are visible by ultrasound at
the start of the cycle, and they can be stimulated
by hormones – either naturally by a woman’s
body or using medications as part of an
assisted-reproduction treatment.
Who is it for?
Revitalize treatment is indicated for patients with a poor prognosis in assisted reproduction treatments due to:
What is the procedure
for the Revitalize
Ovaries treatment?
Revitalize Ovaries by laparoscopy
This procedure is indicated for patients with surgical indication for other reasons. It consists of a minimally invasive intervention carried out at our clinic.
Revitalize Ovaries by puncture
After the very positive experience with the results of Revitalize Ovaries by Laparoscopy, we developed this out-patient technique. This method successfully eliminates fibrosis using non-surgical methods, while achieving the same results as with laparoscopy.
Results of Revitalize Ovaries
The team at the Juana Crespo Clinic has been able to increase by 20% the rate of successful pregnancy in women with very poor reproductive prognosis with their own ova, and whose treatment plan consisted of IVF using donor ova.
In addition, 7% of patients who underwent the Revitalize Ovario procedure achieved natural pregnancy.
Además, el 7% de las pacientes sometidas al procedimiento Revitalize Ovario consiguió embarazo natural.
In addition, 7% of patients who underwent the Revitalize Ovario procedure achieved natural pregnancy.
Revitalize Uterus
This is a comprehensive technique that revitalizes the endometrium and especially the cells of the myometrium-endometrium interface, that is, the subendometrium.
How is the Revitalize
Uterus treatment performed?
In the case of endometrial revitalization, there are two hysteroscopy options that the specialists at Equipo Juana Crespo prescribe depending on the underlying pathology, and they consist of:
-
Pharmacological treatment for the enhancement and mobilization of stem cells.
-
PRGF administration via hysteroscopy.
-
Highly personalized endometrial preparation.
The endometrium is the innermost mucous layer of the uterus, whose main function is to facilitate embryo implantation. The endometrium changes morphologically and functionally throughout the menstrual cycle thanks to the effect of hormones (estrogen and progesterone) and proper vascularization.
Our experience in treating endometria for reproductive purposes has allowed us to develop our own technology in which, through various tests, we select the specific area of the uterus and map the zone where the PRGF micro-injections will be performed, thus maximizing results.
Who is it for?
Revitalize treatment is indicated for patients with a poor prognosis in assisted reproduction treatments due to:
How is the Revitalize Uterus treatment performed?
Revitalize Uterus by hysteroscopy
After stimulating the stem cells, a surgical hysteroscopy is performed to work on the subendometrium and inject the growth factors of the platelet-rich plasma.
FAQS
What is the difference between PRP and PRGF and how do they help in pregnancy?
The terms PRP (platelet-rich plasma) and PRGF (platelet-rich growth factor) are not synonymous, but they often refer to the same technique and are used interchangeably in regenerative therapies. PRP is a concentrate of platelets present in the patient’s blood. PRGF incorporates, in addition to platelets, other components with biological potential such as albumin, immunoglobulins, proteases and antiproteases, fibrinogen, and histamine. This distinction arises from the methodology and method of plasma preparation, resulting in different concentrations and compositions. At Equipo Juana Crespo, we use Endoret, a state-of-the-art technology in regenerative medicine that guarantees the highest quality PRGF, maximizing all its properties. Neither PRGF nor PRP alone can induce pregnancy. At Equipo Juana Crespo, we have developed a comprehensive and integrated procedure that has achieved the highest pregnancy rates after its application.
What is the price of our Revitalize ovarian rejuvenation treatment?
Revitalize, like all our treatments, is completely personalized and part of a comprehensive strategy. The price will depend on the optimal application technique for each patient. If you need more information about prices and procedures, please don’t hesitate to contact us.
Is the Revitalize ovarian rejuvenation treatment painful?
The Revitalize treatment is not painful. In most cases, it is a process very similar to an ovarian puncture. Revitalize Endometrium is always performed via hysteroscopy, making it painless and allowing for immediate recovery.
