What is recurrent miscarriage?
It is classically defined as the consecutive loss of three or more pregnancies before the 20th week of gestation. However, at Equipo Juana Crespo, we adopt a more proactive and compassionate approach.
A Specialised Approach
to a Complex Challenge
At Equipo Juana Crespo, we understand the profound physical and emotional impact of recurrent pregnancy loss. We specialise in providing state-of-the-art medical solutions, supported by science and personalised, compassionate care, for couples facing the challenge of recurrent miscarriage.
We are proud to be a nationally and internationally recognised reference centre, dedicated to offering accurate diagnosis and highly specialised treatments, with a single goal: to make your dream of starting a family a reality.
Following the most recent guidelines from the European Society of Human Reproduction and Embryology (ESHRE, 2023) and the American Society for Reproductive Medicine (ASRM, 2024), we recommend initiating a specialised evaluation after two consecutive pregnancy losses.
We know that starting the assessment early allows underlying causes to be identified sooner, which can significantly improve reproductive prognosis and reduce the emotional burden on the couple.
Classification of
recurrent miscarriage
by obstetric history
Primary recurrent miscarriage
The woman has never had a previous pregnancy that resulted in a live birth.
Secondary recurrent miscarriage
The woman has previously had at least one live birth.
Prevalence
Women of reproductive age
Two losses
1–2% prevalence
Three losses
3-5% prevalence
Recurrent miscarriage affects approximately 1–2% of the population of reproductive age. When the criterion of two losses is considered, this figure rises to 3–5%, highlighting the importance of an early and proactive approach.
Causes of Recurrent
Miscarriage: A
Multifactorial Approach
Recurrent miscarriage is a multifactorial and polyetiological
condition. This means that there is not a single cause; rather, several
factors may coexist in the same patient. At Equipo Juana Crespo,
our diagnostic protocol is designed to investigate all possible causes
in a systematic and comprehensive manner.
Below are the main aetiological groups we evaluate:
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1. Genetic causes
Chromosomal abnormalities in the parents or a high rate of embryonic aneuploidies.
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2. Anatomical causes
Congenital or acquired uterine anomalies
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3. Endocrine causes
Hormonal disorders
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4. Thrombophilic causes
Blood clotting disorders
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5. Immunological causes
Immune rejection of the embryo
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6. Idiopathic recurrent miscarriage
A complete diagnostic work-up fails to identify any underlying cause
Our Diagnostic Protocol:
A Comprehensive and
Personalised Assessment
At Equipo Juana Crespo, diagnosis is the cornerstone of success. We carry out a comprehensive evaluation using the most advanced technology and a multidisciplinary approach.
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Initial consultation and detailed personal and family medical history
01 -
Genetic evaluation
02 -
Advanced uterine assessment
03 -
Tubal evaluation
04 -
Thrombophilia and immunological assessment
05 -
Endocrine and metabolic assessment
06
Our Treatment Strategies
Evidence-Based, Targeted
Solutions
Once the cause has been identified—or even in cases with no known
cause—we establish a fully individualised treatment plan, using the
most advanced assisted reproduction techniques.
Treatment according to aetiology:
For genetic/embryonic causes
-In vitro fertilisation (IVF) with Preimplantation Genetic Testing for Aneuploidies (PGT-A)
-IVF with PGT-SR
For uterine causes
Hysteroscopic surgery:
-Septoplasty
-Myomectomy or polypectomy
-Adhesiolysis
-Revitalize Uterus
-Adenomyosis management
-IVF with deferred embryo transfer
For tubal causes
Unilateral or bilateral salpingectomy.
For thrombophilias (Antiphospholipid syndrome)
Combined protocol with aspirin and low-molecular-weight heparin (LMWH)
For endocrine causes
Hormonal optimisation: Supplementation with levothyroxine, metformin, or medications to control prolactin if elevated.
Comprehensive care
and emotional support
At Equipo Juana Crespo, we know that the journey through infertility and recurrent pregnancy loss is an emotional roller coaster. For this reason, our model of care goes beyond purely medical treatment.
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1. Multidisciplinary approach
We have a team made up of gynaecologists specialised in reproduction, embryologists, urologist-andrologists, and geneticists specialised in fertility. We work in a coordinated manner to provide a 360-degree view of your case.
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2. Genetic counselling
Our geneticists will clearly explain the results of the tests and their implications for your specific situation, helping you make informed decisions.
FAQS
Is it possible to achieve a successful pregnancy after recurrent miscarriages?
A diagnosis of recurrent miscarriage can be overwhelming, but it’s important to convey a message of hope. With an accurate diagnosis and personalized treatment at a highly specialized center like ours, the vast majority of couples will be able to have a healthy baby.
What are the chances of successful treatment in cases of recurrent miscarriages?
Success rates vary depending on the cause, the woman’s age, and other factors, but our commitment is to offer every woman the best possible chance, always using the strongest scientific evidence and the most advanced technologies.
When is it advisable to consult a fertility specialist?
It is recommended to consult after two consecutive pregnancy losses, or earlier if there is advanced maternal age, relevant medical history, or if the patient wishes to receive early guidance.
Can stress or lifestyle influence recurrent miscarriages?
Stress alone is not usually a direct cause, but factors such as smoking, alcohol consumption, being overweight, or certain chronic illnesses can influence reproductive health. A comprehensive approach takes into account both medical aspects and emotional well-being.
